- Luther Burbank, a renowned horticulturist and one of the most famous people of the early 20th Century, called his home Santa Rosa "'the chosen spot of all the earth as far as nature is concerned."
- Charles M. Schulz, creator of the Peanuts cartoon strip, lived and worked in Santa Rosa for over 40 years.
- Santa Rosa has had a long time profitable relationship with the film industry. Alfred Hitchcock's thriller Shadow of a Doubt was filmed in Santa Rosa, and won best original screenplay in 1943. Other films in Santa Rosa include Peggy Sue Got Married and Pollyanna.
- The Wells Fargo Center for the Performing Arts is the largest community-supported non-profit performing and contemporary arts center in the North Bay region. It receives no Federal or State funds, and is instead supported by individual contributions.
- Santa Rosa is a leader in going green with one of the largest city fleets in the state using clean-burning alternative fuels. Currently there are more than 50 pieces of equipment using electricity, compressed natural gas, or propane.
- The Santa Rosa Junior College was recently voted one of the top 10 Junior Colleges in the United States.
- There are over 200 wineries with tasting rooms in Sonoma County and Santa Rosa is home to 7 of these wineries and within 30 minutes of them all.